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Macrophage cell dying in response to TNFR2  

using Nanolive Imaging microscope

The Wong lab is a research lab in Zurich, Switzerland. We focus on understanding the patterns and underlying mechanisms behind cell death signaling and disease.

RESEARCH

Our laboratory is interested in identifying how cell death signaling pathways can influence inflammation with the hope of identifying novel targets to turn on or off the immune system.

Determine how cell death signaling is involved in neo-vascularization and the potential role in vascular disease 

Delineate how the TNF signaling pathways activate the inflammasome and how monogenic autoinflammatory diseases may influence cytokine storms

PUBLICATIONS
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PUBLICATION

RIPK1/RIPK3

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function

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PUBLICATION

TNFR2

Inflammasome activation by TNFR2-specific activation in the absence of XIAP. 

 

  • TNFR2 initiates a NF-kB gene signature and primes inflammasome components

  • Loss of XIAP results in TNFR2-induced pyroptosis

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PUBLICATION

cIAP1

Loss of cIAP1 alters permeability to tumor derived lymphotoxin alpha (title)

  • cIAP1 but not cIAP2 loss in endothelial cells reduces tumor cell extravasation

  • Primary adult endothelial cells in vessels are not susceptible to TNF induced cell death in the absence of cIAP1 and cIAP2 inhibition.

TEACHING
  • BME248: Basics in Immunology

 

Description: This course discusses basic immunology including fundamental characteristics of the innate and adaptive immune systems and the cell types involved, discrimination of self and non-self, as well as the interplay of immune cells in health and disease.

  • BIO431: Cell Death, Inflammation and Immunity, Spring Semester, 2nd Quarter

Description: Students join a laboratory, performing experiments for a current research project. In this course, students will be exposed to issues of data reproducibility, interpretation and presentation.

  • IDB401: Brain Biology

Description: Basic knowledge of the immune system as it pertains to the brain.

  • BIO668: Cancer Module A, Modes of cell death

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University of Zürich

Department of Molecular Life Sciences

© 2021 Designed by: IMMERSION CREATIVE

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